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“Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. This is why zinc ionophores are so important. Aside from hydroxychloroquine, other natural, and safer, zinc ionophores include quercetin and epigallocatechin-gallate (EGCG). If given early, zinc along with a zinc ionophore should, at least theoretically, help lower the viral load and prevent the immune system from becoming overloaded.

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Medical Medium Zinc
Jul 13, 2020 · Quercetin is a safe natural anti-oxidant and anti-inflammatory polyphenolic compound that found in various natural sources include onion, red grapes, honey and citrus fruits. It was shown that quercetin has the ability to chelate zinc ions and act as zinc ionophore. Therefore, quercetin could have antiviral activity against many RNA viruses . Vitamin C and Bio-Quercetin Phytosome´s unique formulation combines high-quality vitamin C with the antioxidant quercetin which complements vitamin C´s activity in supporting whole-body health. In this formula, quercetin has been combined with a phospholipid-based delivery system called phytosome which makes it up to 50 times more absorbable ...

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The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and, thus, many of their ... Zinc is essential for different cellular and enzymatic activities, as well as being a necessary cofactor for many viral proteins [15][16][17][18][19][20][21][22]...
A delivery system based on food-grade lecithin may boost the bioavailability of quercetin, a flavonoid linked to numerous health benefits but known to have poor low water solubility, low stability ... Zinc ionophore is just basically a protein or a gate that allows zinc to come into the cells. We don't know if that is the actual way it is working in this case, but it does seem to lend credence to the mechanism of action that zinc does inhibit replicase and that hydroxychloroquine and chloroquine increase the intracellular concentration of ...

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However, high levels of zinc may reduce Glutathione because zinc has a certain toxicity. RDI for adults is 8-11 mg. Best dietary sources are oysters, beef shanks, chicken legs, pork shoulder and tenderloin, and Alaskan King crab. Zinc from beans, legumes and grains has very low bioavailability compared to meat sources.
Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, et al. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem. 2014 Aug 13;62(32):8085-93. Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, et al. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem 2014;62(32):8085-93. Wu W, Li R, Li X, et bal. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses 2016;8:6. Lu NT, Crespi CM, Liu NM, et al.

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Chloroquine and hydroxychloroquine act as zinc ionophores which help zinc enter cells. Once in the cell the zinc interferes with a virus enzyme and prevents reproducion of the viral RNA. It appears that quercetin (a flavonoid) and EGCG (in green tea) also act like zinc ionophores. Quercetin and zinc supplements are available.
Zinc 50mg with Vitamin C & Quercetin, 4-1 Zinc Complex, 240 Capsules, Immune Support- Up To 8 Months Supply, Premium Zinc Quercetin Supplements 4.8 out of 5 stars 64 3 offers from $21.95 Mar 27, 2020 · Quercetin was demonstrated to be a zinc ionophore in 2014. “Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc.

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Figure 1. Schematic representation of zinc homeostasis. Intracellular labile zinc is modulated by the coordinated activity of a large family of zinc transporters (ZnT and ZIP) and zinc-binding proteins, such as metallothionein or ionophore molecules. - "Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model."
Mar 29, 2020 · Natural quinine and the synthetic forms, chloroquine and hydroxychloraquine are zinc ionophores, i.e. cause cells to take up zinc. They are currently receiving a lot of attention as possible treatments for coronavirus. Mar 31, 2020 · Quercetin as a Zinc Ionophore. Quercetin is a zinc ionophore (13). A 2015 study found that that Quercetin shows inhibitory activity in the early stages of a wide range of influenza viruses, including H1N1 and H5N1 (14).

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was shown to have an independent anti-viral activity [2]. Role of Quercetin as Zn Ionophore Quercetin is a bioflavonoid supplement that has been shown [3] to act as a zinc ionophore, enhancing entrance of zinc into cells to inhibit virus replication (e.g., [4]). Increasing the intracellular
Aug 20, 2020 · Zinc performs an important position in immunity in addition to in blood clotting, 16 cell division, 17 thyroid well being, 18 odor and style, 19 imaginative and prescient 20 and wound therapeutic. 21 It could actually successfully inhibit the replication of viruses in a cell, nevertheless it wants “ionophores” 22 to shuttle it into the cell ...